Air samples versus biomarkers for epidemiology

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Air samples versus biomarkers for epidemiology.

BACKGROUND It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies. METHODS AND RESULTS Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, stable metabolite, macromolecular adduct, or measure of cellular damage. Beca...

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A biomarker is a measurable event occurring in a biological system, such as the human body. In environmental epidemiology, a biomarker represents a subclinical and reversible change; it is not a diagnostic test, but an indicator that an early change has occurred that could later lead to clinical disease. Although some biomarkers may belong to more than one class, they are often separated into b...

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Biomarkers in nutritional epidemiology.

OBJECTIVE To illustrate biomarkers of diet that can be used to validate estimates of dietary intake in the study of gene-environment interactions in complex diseases. DESIGN Prospective cohort studies, studies of biomarkers where diet is carefully controlled. SETTING Free-living individuals, volunteers in metabolic suites. SUBJECTS Male and female human volunteers. RESULTS Recent studie...

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ژورنال

عنوان ژورنال: Occupational and Environmental Medicine

سال: 2005

ISSN: 1351-0711

DOI: 10.1136/oem.2004.013102